Physico-chemicals functions and you can lipids influence In the Pop bioaccumulation

Physico-chemicals functions and you can lipids influence In the Pop bioaccumulation

PCB-twenty-eight inserted adipocytes faster than the almost every other one or two congeners probably due to the quicker molecular pounds, dimensions, and lipophilicity, if you're PCBs ?153 and you may ?118 stayed involved regarding lipophilic telephone membrane and you may diffused a great deal more more sluggish into the intracellular, hydrophobic cytoplasm of one's adipocyte (54)

The latest figure out of toxin buildup inside the and you will discharge from From the is based on the physic-agents characteristics. The newest partition coefficient has proven become a primary parameter governing this new consumption away from lipophilic toxicants with the adipocytes. Yet not, also within good toxicant classification, architectural determinants determine physico-chemical services one dictate On buildup. Including, additional PCB congeners can show collection of use and you may shop dynamics to the adipocytes (54) (250) (249). One data opposed the fresh new buildup potential inside the At off about three PCB congeners: PCB ?28, ?153, and you will ?118 considering each one of the congeners physico-agents enjoys. Show indicated that the dynamics out of accumulation ranged between your congeners because of molecular size, molecular volume, and lipophilicity (54). Especially, the degree of halogenation, otherwise number and you can reputation off chlorine substituents for the PCBs, influenced their consumption and buildup in the adipocytes.

The lipophilicity of a compound depends on its chemical structure, where bigger, more complex and halogenated compounds are typically more lipophilic and resistant to biodegradation (206). As early as the 1900s, researchers tested for lipophilicity by studying the uptake of nonpolar compounds using organic solvents, like octanol, as a surrogate for the organic matter present in organisms (345). Although not identical, the extent of chemical uptake from the water into the organic phase is proportional to what is expected and observed in organisms (345). Читать далее «Physico-chemicals functions and you can lipids influence In the Pop bioaccumulation»