Incident colorectal adenoma
Compared with controls without polyps, incident adenoma cases were more likely to be male, smokers, physically inactive, have higher body mass index, and have higher intake of energy, but had lower intakes of calcium, magnesium and vitamin D (Table 1). However, intakes of calcium between 1200 mg and 1600 mg per day were associated with a significantly reduced risk of incident adenoma with an OR of 0.82 (95% confidence intervals (CI): 0.68–0.97) when compared with calcium intake between 600 and 1200 mg per day (referent group). When analyses were limited to incident advanced and/or synchronous adenomas, the inverse development of associations was found with a corresponding OR of 0.71 (95% CIs: 0.52–0.96) for calcium intake between 1200 and 1600 mg. When these analyses were stratified by the Ca:Mg ratio, the dose–response between calcium fabswingers intake and advanced and/or synchronous adenoma were only observed in participants with a Ca:Mg ratio between 1.7 and 2.5 (P-trend, 0.05). The number of cases in the Ca:Mg ratio < 1.7 strata was too small to make meaningful statistical inference. There was no statistically significant communication between calcium and the Ca:Mg ratio (P-interaction: 0.11).
Metachronous (recurrent) adenoma
In contrast to people instead metachronous adenoma, metachronous adenoma instances have been as well as more likely to getting male and obese, and have higher full times intake however, lower calcium consumption (Dining table step one). Metachronous adenoma instances was in fact less likely to want to end up being white and provides family history regarding CRC.
We didn't observe people mathematically extreme connectivity between calcium supplements intake and you can metachronous adenoma (Table step 3). Читать далее «Zero high dosage–reaction inverse relationship is actually noticed between calcium supplements intake and danger of incident colorectal adenoma (Dining table dos)»